urinary tract infection testing (UTI)

It's quite common for UTIs to be misdiagnosed as routine urine cultures have a high false negative rate. Polymerase chain reaction (PCR) testing finds and copies DNA in a process called amplification. PCR is a powerful tool for identifying both the infectious agent as well as the presence of antibiotic resistance genes. Data shows that UTIs are increasing due to multidrug-resistant pathogens that are spreading globally from the over-prescription and widespread use of broad-spectrum antibiotic therapy instead of a more controlled approach which matches the optimal antibiotics to specific pathogens.

molecular testing or polymerase chain reaction (PCR)

  • detects organisms that cultures miss

  • PCR is over 90% accurate while culture testing ranges around 60-80%

  • identifies more representatives and indicates more positive samples

  • significantly improves patient outcomes through it's accuracy and speed

  • non-inferior to urine culture for detection and identification of bacteria

  • can also be used as a supplemental test along with the routine culture

 

top benefits for PCR testing

  • rapid detection: only 5 hours from sample to result

  • allows for treatment and diagnoses that are narrowly matched to appropriate antibiotic choices

  • increased specificity and sensitivity: over 25% increased accuracy in pathogen detection compared to culture methods

 

case studies

Frontiers - leading open access publisher and science platform out of Switzerland

  • culture identified 278 positive samples of 347 targeted (80.1%)

  • PCR identified 334 positive samples of 347 targeted (95.4%)

  • together they identified a total of 338 samples (97.4%)

 

Renal & Urology News - online medical news website and monthly print publication based in NYC

  • culture identified 15 positive samples of 24 targeted (63%)

  • PCR identified 22 positive samples of 24 targeted (92%)